HOIPIN-8

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.


Cat. No.: EX-A7795	Purity: >98%

	Chemical structure of HOIPIN-8

For research only, Do not use for Human!

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Synonyms	HOIPIN-8 free base
CAS No.	2519537-69-8
Purity	>98%
Formula	C23H16F2N4O3
Mol Weight	434.3949
Color	Off-white to light yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ken Katsuya, et al. Small-molecule Inhibitors of Linear Ubiquitin Chain Assembly Complex (LUBAC), HOIPINs, Suppress NF-κB Signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706.
CoA	CoA of HOIPIN-8

Smiles:	CN1C=C(C=N1)C1=CC=C(C(O)=O)C(\C=C\C(=O)C2=C(F)C=C(C=C2F)C2=CNN=C2)=C1


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