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Product Information:

HM43239

HM43239 is a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations

Cat. No.: EX-A5352    Purity: >98%
Chemical
Chemical structure of HM43239


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
100mg550in_stock
250mg872in_stock
500mg1251in_stock
1g1858in_stock


SynonymsHM-43239
Synonyms 2Tuspetinib
CAS No.2294874-49-8
Purity>98%
FormulaC29H33ClN6
Mol Weight501.066
ColorWhite to off-white
Statesolid powder
SolubilitySoluble in DMSO 125 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, protect from light; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Miyoung Lee, et.al. Abstract 804: Antitumor activity of the potent and novel FLT3 inhibitor HM43239 in acute myeloid leukemia. Cancer Res July 1 2018 (78) (13 Supplement) 804.

[2]. Naval G. Daver, et.al. HM43239, a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations: Phase 1 /2 Study. Blood 2019; 134 (Supplement_1): 1331.

[3]. JiSook Kim, et.al. Abstract 1293: HM43239, a novel FLT3 inhibitor in overcoming resistance for acute myeloid leukemia. Cancer Res July 1 2019 (79) (13 Supplement) 1293.

CoACoA of HM43239
Smiles:C[C@H]1CN(CC2=CC(=CC(NC3=NC=C(Cl)C(=N3)C3=CNC4=C3C=CC(C)=C4)=C2)C2CC2)C[C@@H](C)N1

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