HG-9-91-01

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively.


Cat. No.: EX-A1279	Purity: >98%

	Chemical structure of HG-9-91-01

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	450	In-stock
50mg	720	In-stock
100g	1150	In-stock
250g	2300	In-stock
500g	3680	In-stock
1g	5890	In-stock

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CAS No.	1456858-58-4
Purity	>98%
Formula	C32H37N7O3
Mol Weight	567.6813
State	solid powder
Solubility	DMSO > 30mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. [2]. Sundberg TB, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12468-73. [3]. Patel K, et al.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 4;5:4535. [4]. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184.
CoA	CoA of HG-9-91-01

Smiles:	COC1=CC=C(N(C(=O)NC2=C(C)C=CC=C2C)C2=CC(NC3=CC=C(C=C3)N3CCN(C)CC3)=NC=N2)C(OC)=C1


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