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Product Information:

HDAC/JAK/BRD4-IN-1

HDAC/JAK/BRD4-IN-1(compound 25ap) is a potent HDAC/JAK/BRD4 triple inhibitor. HDAC/JAK/BRD4-IN-1 inhibit cell growth and induces apoptosis in MDA-MB-231 cells, and shows anticancer activity in vivo .

Cat. No.: EX-A8766    Purity: >98%
Chemical
Chemical structure of HDAC/JAK/BRD4-IN-1


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
25mg750Inquire
50mg985Inquire
100mg1550Inquire
250mgget quoteInquire
500mgget quoteInquire
1gget quoteInquire


CAS No.2755325-84-7
Purity>98%
FormulaC24H28N6O3
Mol Weight448.5175
SolubilityDMSO : 100 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years , 4°C, 2 years ; In solvent   -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Zhao C, et al. Discovery of Novel Fedratinib-Based HDAC/JAK/BRD4 Triple Inhibitors with Remarkable Antitumor Activity against Triple Negative Breast Cancer [published online ahead of print, 2023 Oct 5]. J Med Chem. 2023;10.1021/acs.jmedchem.3c01242.

CoACoA of HDAC/JAK/BRD4-IN-1
Smiles:ONC(C1=CC=C(C=C1)NC2=NC(NC3=CC=C(OCCN4CCCC4)C=C3)=NC=C2C)=O

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