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Product Information:

HDAC-IN-37

HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis .

Cat. No.: EX-A17411    Purity: >98%
Chemical
Chemical structure of HDAC-IN-37


For research only, Do not use for Human!

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CAS No.2766466-56-0
Purity>98%
FormulaC23H24ClN7O
Mol Weight449.936
 
 
Reference:  

[1].Mao PT, He WB, Mai X, et al. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorg Med Chem.

CoACoA of HDAC-IN-37
Smiles:CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O

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