hCYP1B1-IN-2

hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM.


Cat. No.: EX-A12959	Purity: >98%

	Chemical structure of hCYP1B1-IN-2

For research only, Do not use for Human!

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CAS No.	3043683-33-3
Purity	>98%
Formula	C17H10BrN3O2
Mol Weight	368.184
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wei Y, et al. Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors. Bioorg Med Chem Lett. 2024 Jul 15;107:129776.
CoA	CoA of hCYP1B1-IN-2

Smiles:	O=C1C=2C=CC=C3C(Br)=CC=C(C(=O)N1CC=4C=NC=NC4)C32


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