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Product Information:

hAChE/hBACE-1-IN-3

hAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier .

Cat. No.: EX-A16004    Purity: >98%
Chemical
Chemical structure of hAChE/hBACE-1-IN-3


For research only, Do not use for Human!

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CAS No.3026984-15-3
Purity>98%
FormulaC25H31N3O3
Mol Weight421.5319
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Banoo R, et al. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and β-secretase inhibitors. Eur J Med Chem. 2024 Jan 6;266:116131.

CoACoA of hAChE/hBACE-1-IN-3
Smiles:O=C(NCCC1CCN(CC=2C=CC=CC2)CC1)C3=CC=4C=C(OC)C(OC)=CC4N3

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