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Product Information:

HA-155

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM .

Cat. No.: EX-A8520    Purity: >98%
Chemical
Chemical structure of HA-155


For research only, Do not use for Human!

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CAS No.1312201-00-5
Purity>98%
FormulaC25H23BFNO5S
Mol Weight479.328
ColorWhite to off-white
Statesolid powder
SolubilityDMSO : 10 mg/mL
Shelf Life>3 years if stored properly
StoragePowder   -20°C, 3 years ; In solvent  -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Albers HM, et al. Chemical Evolution of Autotaxin Inhibitors. Chem Rev. 2012 May 9;112(5):2593-603.

[2]. Albers HM, et al. Structure-based design of novel boronic acid-based inhibitors of autotaxin. J Med Chem. 2011 Jul 14;54(13):4619-26.

[3]. Fulkerson Z, et al. Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells. J Biol Chem. 2011 Oct 7;286(40):34654-63.

CoACoA of HA-155
Smiles:O=C1N(CC2=CC=C(F)C=C2)C(S/C1=C\C3=CC=C(OCC4=CC=C(B(O)O)C=C4)C=C3)=O.[(Z)]

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