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Product Information:

GZD824

GZD824 (HQP1351) is an orally bioavailable Bcr-Abl inhibitor for Bcr-Abl (WT) and Bcr-Abl (T315I) with IC50s of 0.34 nM and 0.68 nM, respectively.

Cat. No.: EX-A829    Purity: >98%
Chemical
Chemical structure of GZD824


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
200mg550In-stock
500mg700In-stock
1g1050In-stock
5g2650In-stock
10g3880In-stock


SynonymsHQP1351
CAS No.1257628-77-5
Purity>98%
FormulaC29H27F3N6O
Mol Weight532.5595
Statesolid powder
SolubilityDMSO > 100 mg/mL
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  [1]. Ren X, Pan X, Zhang Z, Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. 2013 Feb 14;56(3):879-94.
CoACoA of GZD824
Smiles:CN1CCN(CC2=CC=C(NC(=O)C3=CC=C(C)C(=C3)C#CC3=CN=C4NN=CC4=C3)C=C2C(F)(F)F)CC1

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