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Product Information:

GW4064

GW 4064 is a potent FXR agonist with an EC50 of 65 nM.

Cat. No.: EX-A1383    Purity: >98%
Chemical
Chemical structure of GW4064


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg500In-stock
500mg685In-stock
1g985In-stock
2g1550In-stock


SynonymsGW 4064
CAS No.278779-30-9
Purity>98%
FormulaC28H22Cl3NO4
Mol Weight542.838
Statesolid powder
SolubilitySoluble in DMSO, DMF
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Akwabi-Ameyaw A, et al.Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.

[2]. Liu Y, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest. 2003 Dec;112(11):1678-87.

CoACoA of GW4064
Smiles:CC(C)C1=C(COC2=CC(Cl)=C(\C=C\C3=CC(=CC=C3)C(O)=O)C=C2)C(=NO1)C1=C(Cl)C=CC=C1Cl

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