GW273297X

GW273297X is a selective CYP27A1 inhibitor. GW273297X blocks 27-hydroxycholesterol biosynthesis and sterol product formation in human macrophages. GW273297X reduces cancer cells colonization by inhibiting pro-metastatic effects of 27-hydroxycholesterol. GW273297X can be used for the researches of cancer and metabolic disease, such as breast cancer.


Cat. No.: EX-A13284	Purity: >98%

	Chemical structure of GW273297X

For research only, Do not use for Human!

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CAS No.	1713317-28-2
Purity	>98%
Formula	C29H48O3
Mol Weight	444.6896
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Baek AE, et al. The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells. Nat Commun. 2017;8(1):864. Published 2017 Oct 11. [2]. Quinn CM, et al. Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands. Biochem J. 2005;385(Pt 3):823-830.
CoA	CoA of GW273297X

Smiles:	C[C@@]12[C@](CC[C@@H]2[C@H](C)CCCCC#C)([H])[C@]3([H])[C@@H](O)C[C@]4([H])CC(OC)(OC)CC[C@]4(C)[C@@]3([H])CC1


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