Gut restricted-7

Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .


Cat. No.: EX-A10211	Purity: >98%

	Chemical structure of Gut restricted-7

For research only, Do not use for Human!

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Synonyms	GR-7
CAS No.	2553218-46-3
Purity	>98%
Formula	C25H40FNaO6S
Mol Weight	510.635
Color	White to off-white
State	Solid
Solubility	soluble in DMSO/H2O
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture; In solvent -20°C, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326.
CoA	CoA of Gut restricted-7

Smiles:	O=C(CF)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C


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