GSK8814

GSK8814 is a potent, selective, and ATAD2/2B bromodomain chemical probe and inhibitor, with a binding constant pKd=8.1 and a pKi=8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1.


Cat. No.: EX-A5089	Purity: >98%

	Chemical structure of GSK8814

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	850	Inquire
10mg	1350	Inquire
50mg	2500	Inquire
250mg	get quote

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CAS No.	1997369-78-4
Purity	>98%
Formula	C28H35F2N5O3
Mol Weight	527.606
Color	Light yellow to yellow
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Bamborough P, et al. A Chemical Probe for the ATAD2 Bromodomain. Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11382-6.
CoA	CoA of GSK8814

Smiles:	O=C1NC2=C(N[C@H]3[C@H](OCC4CCC(F)(F)CC4)CNC[C@@H]3OC)N=CC(C5=CC(C)=CN=C5)=C2C=C1C


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