GSK805

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity .


Cat. No.: EX-A2975	Purity: >98%

	Chemical structure of GSK805

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	447	in_stock
250mg	840	in_stock
500mg	1346	in_stock
1g	2166	in_stock
2g	3346	in_stock
3g	4194	in_stock

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CAS No.	1426802-50-7
Purity	>98%
Formula	C23H18Cl2F3NO4S
Mol Weight	532.36
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang Y, et al. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors. ACS Med Chem Lett. 2015 May 26;6(7):787-792. [2]. Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40(4):477-89.
CoA	CoA of GSK805

Smiles:	CCS(=O)(=O)C1=CC=C(CC(=O)NC2=CC(Cl)=C(C(Cl)=C2)C2=CC=CC=C2OC(F)(F)F)C=C1


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