GSK4418959

GSK4418959 (IDE275) is a non-covalent, reversible, selective and orally active WRN helicase inhibitor. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer .


Cat. No.: EX-A12462	Purity: >98%

	Chemical structure of GSK4418959

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	340	In-stock
10mg	540	In-stock
25mg	1060	In-stock
50mg	1740	In-stock
100mg	2760	In-stock
250mg	5570	In-stock

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	IDE275
CAS No.	3064599-36-3
Purity	>98%
Formula	C31H30F4N4O5S
Mol Weight	646.652
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Joshua P. Taygerly, et al. Abstract 5750: Discovery of GSK4418959 (IDE275): A novel, non-covalent, reversible Werner Helicase inhibitor and a new potential therapeutic for the treatment of MSI-H cancers. Cancer Res (2025) 85 (8_Supplement_1): 5750.
CoA	CoA of GSK4418959

Smiles:	O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O


		Search