GSK321

GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular α-Hydroxyglutaric acid (2-HG), abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers


Cat. No.: EX-A14122	Purity: >98%

	Chemical structure of GSK321

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	650	Inquire
100mg	950	Inquire
250mg	1350	Inquire
500mg	1850	Inquire
1g	2450

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CAS No.	1816331-63-1
Purity	>98%
Formula	C28H28FN5O3
Mol Weight	501.552
Color	Off-white to light brown
State	Solid
Solubility	DMSO : 250 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, protect from light; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ujunwa C Okoye-Okafor, et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015 Nov;11(11):878-86.
CoA	CoA of GSK321

Smiles:	O=C(C1=CC=CN1)N2C[C@@H](C)C(N(CC3=CC=C(F)C=C3)N=C4C(NC5=CC([C@H](C)O)=CC=C5)=O)=C4C2


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