GSK1904529A

GSK1904529A is a potent, selective, orally active, and ATP-competitive inhibitor of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR), with IC50s of 27 and 25 nM, respectively. GSK1904529A shows poor activity (IC50>1 μM) in 45 other serine/threonine and tyrosine kinases. GSK1904529A exhibits anti-tumor activity.


Cat. No.: EX-A008	Purity: >98%

	Chemical structure of GSK1904529A

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	498	In-stock
250mg	980	In-stock
500mg	1580	In-stock
1g	2480	In-stock
2g	4010	In-stock
3g	4800	In-stock

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CAS No.	1089283-49-7
Purity	>98%
Formula	C44H47F2N9O5S
Mol Weight	851.963
Color	light yellow to yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sabbatini P, et al. Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase. Clin Cancer Res, 2009, 15(9), 3058-3067. [2]. Zhou Q, et, al. GSK1904529A, an insulin-like growth factor-1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration. Mol Med Rep. 2015 Sep;12(3):3381-3385.
CoA	CoA of GSK1904529A

Smiles:	CCC1=C(C=C(OC)C(NC2=NC=CC(=N2)C2=C(N=C3C=CC=CN23)C2=CC=C(OC)C(=C2)C(=O)NC2=C(F)C=CC=C2F)=C1)N1CCC(CC1)N1CCN(CC1)S(C)(=O)=O


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