GSK189254A

GSK189254A (GSK189254 free base) is a novel, potent and selective histamine H3 receptor antagonist with pKi values of 9.59-9.90 and 8.51-9.17 for human and rat H3, respectively.


Cat. No.: EX-A1905	Purity: >98%

	Chemical structure of GSK189254A

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	950	In-stock
500mg	1350	In-stock
1g	1995	In-stock
5g	get quote	In-stock

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CAS No.	720690-73-3
Purity	>98%
Formula	C21H25N3O2
Mol Weight	351.4421
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Medhurst AD, et al. GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models. J Pharmacol Exp Ther. 2007 Jun;321(3):1032-45. [2]. Guo RX, et al. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice.Br J Pharmacol. 2009 May;157(1):104-17.
CoA	CoA of GSK189254A

Smiles:	CNC(=O)C1=CN=C(OC2=CC3=C(CCN(CC3)C3CCC3)C=C2)C=C1


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