GSK143 dihydrochloride

GSK143 dihydrochloride is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 dihydrochloride inhibits phosphorylated Erk (pErk: pIC50=7.1). GSK143 dihydrochloride reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice.


Cat. No.: EX-A10753	Purity: >98%

	Chemical structure of GSK143 dihydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	1150	In-stock
500mg	1850	In-stock
1g	2750	In-stock

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CAS No.	2341796-81-2
Purity	>98%
Formula	C17H24Cl2N6O2
Mol Weight	415.317
Color	off-white to light yellow
State	solid
Solubility	Soluble in DMSO/H2O
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture and light, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. John Liddle, et al. Discovery of GSK143, a Highly Potent, Selective and Orally Efficacious Spleen Tyrosine Kinase Inhibitor. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. [2]. Abraham M Varghese, et al. Highly Selective SYK Inhibitor, GSK143, Abrogates Survival Signals in Chronic Lymphocytic Leukaemia. Br J Haematol. 2018 Sep;182(6):927-930. [3]. Sjoerd H W van Bree, et al. Inhibition of Spleen Tyrosine Kinase as Treatment of Postoperative Ileus. Gut. 2013 Nov;62(11):1581-90.
CoA	CoA of GSK143 dihydrochloride

Smiles:	[H]Cl.[H]Cl.O=C(C1=CN=C(N[C@H]2[C@@H](N)COCC2)N=C1NC3=CC=C(C)C=C3)N


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