GSK046

GSK046 (iBET-BD2) is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively.


Cat. No.: EX-A4796	Purity: 98+%

	Chemical structure of GSK046

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
50mg	650	Inquire
100mg	850	In-stock
250mg	1400	In-stock
500mg	2000	In-stock
1g	2800	In-stock
5g	get quote	Inquire

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Synonyms	iBET-BD2
CAS No.	2474876-09-8
Purity	98+%
Formula	C23H27FN2O4
Mol Weight	414.4699
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368(6489): 387-394. [2] Alex Preston, et al. Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins. J Med Chem. 2020 Sep 10;63(17):9070-9092.
CoA	CoA of GSK046

Smiles:	O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2


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