GSK-1838705A

GSK1838705A is a potent and reversible IGF-IR and the insulin receptor inhibitor with IC50s of 2.0 and 1.6 nM, respectively. It also inhibits ALK with an IC50 of 0.5 nM.


Cat. No.: EX-A11280	Purity: >98%

	Chemical structure of GSK-1838705A

For research only, Do not use for Human!

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CAS No.	1186659-59-5
Purity	>98%
Formula	C27H27FN8O3
Mol Weight	530.5535
Color	Light yellow to yellow
State	solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sabbatini P, et al. GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers. Mol Cancer Ther. 2009 Oct;8(10):2811-20.
CoA	CoA of GSK-1838705A

Smiles:	O=C(NC)C=1C(F)=CC=CC1NC=2N=C(N=C3NC=CC32)NC4=CC5=C(C=CN5C(=O)CN(C)C)C=C4OC


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