GSA 10

GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development.


Cat. No.: EX-A14248	Purity: >98%

	Chemical structure of GSA 10

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	650	In-stock
250mg	1050	In-stock
500mg	1550	In-stock
1g	2150	In-stock

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CAS No.	300833-95-8
Purity	>98%
Formula	C26H30N2O5
Mol Weight	450.5268
Color	White to light yellow
State	Solid
Solubility	DMSO : 1.67 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Mol Pharmacol. 2013 May;83(5):1020-9. [2]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016 Oct 4;121:747-757. [3]. Fleury A, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016 Mar 24;6:23479. doi: 10.1038/srep23479. PMID: 27010359; PMCID: PMC4806302.
CoA	CoA of GSA 10

Smiles:	CCCCCCN1C2=CC=CC=C2C(=C(C1=O)C(=O)NC3=CC=C(C=C3)C(=O)OCCC)O


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