GRL-0496

GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM .


Cat. No.: EX-A10768	Purity: >98%

	Chemical structure of GRL-0496

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	650	In-stock
500mg	950	In-stock
1g	1550	In-stock
5g	get quote	In-stock

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CAS No.	1087243-14-8
Purity	>98%
Formula	C14H9ClN2O2
Mol Weight	272.686
Color	light yellow to green yellow
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.
CoA	CoA of GRL-0496

Smiles:	O=C(C1=CC=CC2=C1C=CN2)OC3=CC(Cl)=CN=C3


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