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Product Information:

GPX4-IN-13

GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM) .

Cat. No.: EX-A9868    Purity: >98%
Chemical
Chemical structure of GPX4-IN-13


For research only, Do not use for Human!

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CAS No.2644044-43-7
Purity>98%
FormulaC23H15NO3
Mol Weight353.3701
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Can be arranged to be shipped with ice bag upon request.
 
 
Reference:  

[1]. Pamarthy, et al. "Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells." Drug Development Research 84.5 (2023): 861-887.

CoACoA of GPX4-IN-13
Smiles:O=CC1=C(OC2=C(\C=C\C(=O)C3=CC=C(C=C3)C#N)C=CC=C2)C=CC=C1

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