GNF-5

GNF-5, the N-hydroxyethyl carboxamide analog of GNF-2, is an orally active Bcr-Abl inhibitor. GNF-5 has Bcr-Abl inhibition activity with an IC50 value of 0.22 µM. GNF-5 has good favorable pharmacokinetic properties. GNF-5 can be used for the research of kinds of cancer including chronic myelogenous leukemia (CML) and breast cancer .


Cat. No.: EX-A312	Purity: >98%

	Chemical structure of GNF-5

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
500mg	648	in_stock
1g	1008	in_stock
2g	1654	in_stock
5g	3088	in_stock
10g	4827	in_stock

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CAS No.	778277-15-9
Purity	>98%
Formula	C20H17F3N4O3
Mol Weight	418.3692
Color	White to off-white
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Zhang J, et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature. 2010 Jan 28;463(7280):501-6. [2]. Meirson T, et al. Targeting invadopodia-mediated breast cancer metastasis by using ABL kinase inhibitors. Oncotarget. 2018 Apr 24;9(31):22158-22183.
CoA	CoA of GNF-5

Smiles:	OCCNC(=O)C1=CC=CC(=C1)C1=NC=NC(NC2=CC=C(OC(F)(F)F)C=C2)=C1


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