GNE-8025

GNE-8025 is an orally active pan-TEAD transcription factor inhibitor, with IC50 values of 45, 38, 1035 and 24 nM against TEAD1, TEAD2, TEAD3 and TEAD4, respectively. GNE-8025 allosterically disrupts the TEAD-YAP/TAZ interaction and inhibits TEAD-mediated oncogenic transcriptional programs via the Hippo signaling pathway. GNE-8025 suppresses YAP-driven tumor cell growth. GNE-8025 enhances the activity of MAPK and KRAS G12C inhibitors. GNE-8025 can be used for the research of pleural mesothelioma and KRAS G12C-mutant cancers .


Cat. No.: EX-A17446	Purity: >98%

	Chemical structure of GNE-8025

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
5mg	768	Inquire
10mg	988	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2933893-27-5
Purity	>98%
Formula	C19H17F3N4O4
Mol Weight	422.3579

Reference:	[1].Hagenbeek TJ, et al. Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model. Nature communications. 2026 Jun 27.
CoA	CoA of GNE-8025

Smiles:	C(NC(C=C)=O)C=1C=2C(N(N1)C3=CC=C(OC(F)(F)F)C=C3)=NC=CC2[C@@H](CO)O


		Search