GNE-781

GNE-781 is an orally active, highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. GNE-781 displays antitumor activity in an MOLM-16 AML xenograft model.


Cat. No.: EX-A8317	Purity: >98%

	Chemical structure of GNE-781

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	600	In-stock
250mg	950	In-stock
500mg	1650	In-stock
1g	2900	In-stock
5g	get quote	In-stock
10g	get quote	In-stock

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Synonyms	GNE781
CAS No.	1936422-33-1
Purity	>98%
Formula	C27H33F2N7O2
Mol Weight	525.5934
Color	Light yellow to yellow
State	solid powder
Solubility	DMSO : 50 mg/mL
Shelf Life	>1 years if stored properly
Storage	-20°C, stored under nitrogen
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Romero FA, et al. GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Nov 22;60(22):9162-9183.
CoA	CoA of GNE-781

Smiles:	O=C(NC)N1CC=2C(=NN(C2CC1)C3CCOCC3)N4C=5C=C(C(=CC5CCC4)C=6C=NN(C6)C)C(F)F


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