GNE-6468

GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC .


Cat. No.: EX-A16644	Purity: >98%

	Chemical structure of GNE-6468

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	get quote

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CAS No.	1677668-27-7
Purity	>98%
Formula	C23H16ClN3O4
Mol Weight	433.844
Color	Light yellow to yellow
State	solid
Solubility	DMSO : 5 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20℃, sealed, 3 years; 4℃, sealed, 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Fauber BP, et al. Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2907-12.
CoA	CoA of GNE-6468

Smiles:	C1CC1C2=C(C(=CC=C2)Cl)C(=O)C3=NC(=C4N3C=CC=N4)C5=CC(=C(C=C5)C(=O)O)O


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