GNE-375

GNE-375 is a potent and highly selective BRD9 inhibitor with an IC50 of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin .


Cat. No.: EX-A9435	Purity: >98%

	Chemical structure of GNE-375

For research only, Do not use for Human!

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CAS No.	1926989-06-1
Purity	>98%
Formula	C25H29N3O5
Mol Weight	451.5149
Color	Off-white to pink
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Terry D Crawford, et al. Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3534-3541.
CoA	CoA of GNE-375

Smiles:	O=C1C(NC(C)=C2)=C2C(C3=CC(OC)=C(C(N4CCOCC4)=O)C=C3OC)=CN1C/C=C/C


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