GNE-2256

GNE-2256 (molecule 19), a chemical probe, is an orally active IRAK4 (Interleukin 1 receptor associated kinase 4) inhibitor (IRAK4 Ki=1.4 nM; IL-6 IC50=190 nM) .


Cat. No.: EX-A6367	Purity: >98%

	Chemical structure of GNE-2256

For research only, Do not use for Human!

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CAS No.	2102170-43-2
Purity	>98%
Formula	C24H27FN6O4
Mol Weight	482.5074
Color	off-white
State	solid powder
Solubility	Soluble in DMSO 50 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Rajapaksa NS, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett. 2019 Nov 11;11(3):327-333.
CoA	CoA of GNE-2256


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