GNE-2181

GNE-2181 is an orally active, blood-brain barrier-penetrant pan-TEAD transcription factor inhibitor, with IC50 values of 13, 26, 61 and 17 nM against TEAD1, TEAD2, TEAD3 and TEAD4, respectively. GNE-8021 allosterically disrupts the TEAD-YAP/TAZ interaction and inhibits TEAD-mediated oncogenic transcriptional programs via the Hippo signaling pathway. GNE-8021 suppresses YAP-driven tumor cell growth. GNE-2181 inhibits the growth of intracranial tumor models in vivo. GNE-2181 can be used for research on brain metastasis of lung cancer .


Cat. No.: EX-A17412	Purity: >98%

	Chemical structure of GNE-2181

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
5mg	495	Inquire
10mg	795	Inquire

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


CAS No.	2933893-78-6
Purity	>98%
Formula	C20H16F4N4O3
Mol Weight	436.3597

Reference:	[1].Hagenbeek TJ, et al. Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model. Nature communications. 2026 Jun 27.
CoA	CoA of GNE-2181

Smiles:	C=C(C(N1CC(C1)C2=NN(C3=C2C(CO)=CC=N3)C4=CC=C(C=C4)OC(F)(F)F)=O)F


		Search