GMB-475

GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.


Cat. No.: EX-A3614	Purity: >98%

	Chemical structure of GMB-475

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	623	in_stock
250mg	1028	in_stock
500mg	1654	in_stock
1g	2795	in_stock
2g	3174	in_stock

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Synonyms	2489876-37-9
CAS No.	2490599-18-1
Purity	>98%
Formula	C43H46F3N7O7S
Mol Weight	861.928
Color	white to off-white
State	powder
Solubility	Soluble in DMSO, not in water
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.
CoA	CoA of GMB-475

Smiles:	FC(F)(F)OC1=CC=C(NC2=CC(C3=CC=C(OCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(NCC5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)C=C3)=NC=N2)C=C1


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