Glutaminyl cyclases-IN-1

Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages.


Cat. No.: EX-A17057	Purity: >98%

	Chemical structure of Glutaminyl cyclases-IN-1

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
5mg	get quote
10mg	get quote
25mg	get quote
50mg	get quote
100mg	get quote
200mg	get quote

Send PO to E-mail:[email protected]; or Fax:+86 020 81619670

Discount Request


Synonyms	1,3,4-Thiadiazol-2-amine, 5-[1-[[3-methoxy-4-[3-(1-piperidinyl)propoxy]phenyl]methyl]-1H-benzimidazol-5-yl]-
CAS No.	3032400-33-9
Purity	>98%
Formula	C25H30N6O2S
Mol Weight	478.61
Color	White to off-white
State	Solid
Solubility	DMSO : 100 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder -20°C 3 years, 4°C 2 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Eunsun Park, et al. 2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint. ACS Med. Chem. Lett. 2022.
CoA	CoA of Glutaminyl cyclases-IN-1

Smiles:	COC1=C(C=CC(CN2C=NC3=CC(C4=NN=C(S4)N)=CC=C32)=C1)OCCCN5CCCCC5


		Search