GLPG3312

GLPG3312 (Compound 28) is a selective pan-SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively. GLPG3312 exhibits anti-inflammatory and immunomodulatory activity in vitro on human primary myeloid cells and in vivo in mouse models. GLPG3312 has good oral bioavailability and can be used for research on inflammatory and immune diseases.


Cat. No.: EX-A11376	Purity: >98%

	Chemical structure of GLPG3312

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
100mg	985	In-stock
250mg	1480	In-stock
500mg	2080	In-stock
1g	2880	In-stock

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CAS No.	2340388-72-7
Purity	>98%
Formula	C23H21F2N5O3
Mol Weight	453.4413
Color	White to off-white
State	solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Temal-Laib T, et al. Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J Med Chem. 2024 Jan 11;67(1):380-401.
CoA	CoA of GLPG3312

Smiles:	O=C(NC1CC1)C2=C(OC)C=C(N3C=NC4=CC(C5=CN(C)N=C5)=CC=C34)C=C2OC(F)F


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