GLPG0187

GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM. GLPG0187 inhibits migrasome biogenesis without cytotoxicity.


Cat. No.: EX-A1730	Purity: >98%

	Chemical structure of GLPG0187

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	577	in_stock
500mg	927	in_stock
1g	1535	in_stock

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CAS No.	1320346-97-1
Purity	>98%
Formula	C29H37N7O5S
Mol Weight	595.713
State	solid powder
Solubility	Soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. van der Horst G, et al. Targeting of α(v)-integrins in stem/progenitor cells and supportive microenvironment impairs bone metastasis in human prostate cancer. Neoplasia. 2011 Jun;13(6):516-25. [2]. Puzhong Lu, et al. Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discov. 2020 Aug 4;6(1):51. [3]. Reeves KJ, et al. Prostate cancer cells home to bone using a novel in vivo model: modulation by the integrin antagonist GLPG0187. Int J Cancer. 2015 Apr 1;136(7):1731-40.
CoA	CoA of GLPG0187

Smiles:	COC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CNC1=NC(C)=NC(N2CCC(CC2)C2=NC3=C(CCCN3)C=C2)=C1C)C(O)=O


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