GK444

GK444 (Compound 15a) is a HDAC1/2 inhibitor (IC50: 100 and 92 nM for HDAC1/2 respectively). GK444 inhibits Caco-2 cells with IC50 of 4.1 μM. GK444 also reduces TGF-β1 induced COL1A1 mRNA levels in primary normal human lung fibroblasts. GK444 inhibits Bleomycin -induced lung fibrosis in mice.


Cat. No.: EX-A11666	Purity: >98%

	Chemical structure of GK444

For research only, Do not use for Human!

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CAS No.	3032392-39-2
Purity	>98%
Formula	C33H32N4O4
Mol Weight	548.6316
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Gerokonstantis DT, et al. N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. J Med Chem. 2023 Oct 26;66(20):14357-14376.
CoA	CoA of GK444

Smiles:	C(N1[C@H](C(NCC2=CC=C(OCC3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)C=C2)=O)CCC1=O)C5=CC=CC=C5


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