Gintemetostat

KTX-1001 is a novel, potent NSD2 (nuclear receptor-binding SET domain protein 2) inhibitor. KTX-1001 selectively targets and binds to NSD2, and inhibits its catalytic activity and the mono- and di-methylation of histone H3 lysine 36 (H3K36).


Cat. No.: EX-A5782	Purity: >98%

	Chemical structure of Gintemetostat

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
5mg	300	In-stock
10mg	500	In-stock
25mg	850	In-stock
50mg	1450	In-stock
100mg	2100	In-stock
250mg	3900	In-stock

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Synonyms	KTX-1001
Synonyms 2	NSD2 inhibitor-1
CAS No.	2604513-16-6
Purity	>98%
Formula	C25H26F4N8O2
Mol Weight	546.52
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Ma, Zonghui et al. “Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).” Journal of medicinal chemistry vol. 66,16 (2023): 10991-11026. doi:10.1021/acs.jmedchem.3c00948 [2].Deng, Haibing; Liu, Jinbiao; Oyang, Counde; Wang, Ce; Xiao, Qitao; Xun, Guoliang; Zeng, Haiqiang. Piperidinyl-methyl-purinamines as NSD2 inhibitors and anti-cancer agents and their preparation. WO2021028854 A1 [3]. He, Lin et al. “NSD family proteins: Rising stars as therapeutic targets.” Cell insight vol. 3,2 100151. 3 Feb. 2024, doi:10.1016/j.cellin.2024.100151
CoA	CoA of Gintemetostat


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