GFOGER

GFOGER peptide is an artificially synthesized collagen-mimetic sequence. GFOGER peptide acts as a ligand for α2β1, α11β1 and α1β1 integrins, thereby supporting integrin-mediated cell adhesion to collagen. GFOGER peptide triggers signaling pathways mediated by the α2β1 integrin receptor and upregulates osteoblast differentiation. GFOGER peptide accelerates and enhances bone formation at sites of refractory femoral defects. GFOGER peptide can be passively adsorbed onto polymer scaffolds for cell-free/growth factor-free bone formation. GFOGER peptide is used in biomaterials such as hydrogels and 3D bioinks for tissue engineering research including bone formation .


Cat. No.: EX-A17209	Purity: >98%

	Chemical structure of GFOGER

For research only, Do not use for Human!

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CAS No.	245120-10-9
Purity	>98%
Formula	C29H43N9O10
Mol Weight	677.706
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -20°C, sealed storage, away from moisture; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wojtowicz AM, et al. Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair. Biomaterials. 2010;31(9):2574-2582. [2]. Zhang WM, et al. alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens. J Biol Chem. 2003 Feb 28;278(9):7270-7. [3]. Mansour A, et al. GFOGER Peptide Modifies the Protein Content of Extracellular Vesicles and Inhibits Vascular Calcification. Front Cell Dev Biol. 2020;8:589761. Published 2020 Nov 30.
CoA	CoA of GFOGER

Smiles:	C([C@H](CC1=CC=CC=C1)NC(CN)=O)(=O)N2[C@H](C(NCC(N[C@H](C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)CCC(O)=O)=O)=O)C[C@@H](O)C2


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