GEA 3162

GEA 3162 is an orally active compound that acts as a NO/ONOO⁻ donor. GEA 3162 significantly inhibits the activation of human polymorphonuclear leukocytes (PMNs) through the cGMP pathway, inhibits the release of inflammatory mediators, and exerts anti-inflammatory and protective effects. GEA 3162 induces apoptosis of neutrophils and bone marrow cells by activating caspase-2/3/8/9 through the ONOO⁻ pathway. GEA 3162 has a bidirectional effect in the rat gastric ulcer model: at low doses, it significantly reduces gastric mucosal damage, while at high doses, it aggravates the ulcer area. GEA 3162 can be used for research on inflammatory conditions such as gastric ulcers .


Cat. No.: EX-A10786	Purity: >98%

	Chemical structure of GEA 3162

For research only, Do not use for Human!

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CAS No.	144576-10-3
Purity	>98%
Formula	C7H4Cl2N4O
Mol Weight	231.039
Color	Off-white to light yellow
State	Solid
Solubility	Soluble in DMSO
Shelf Life	>3 years if stored properly
Storage	Powder -20℃ 3 years, 4℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Moilanen E, et al. Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions. Br J Pharmacol. 1993;109(3):852-858. [2]. Taylor EL, et al. GEA 3162 hydrochloride decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism. Br J Pharmacol. 2004 Sep;143(1):179-85. [3]. Taylor EL, et al. GEA 3162, a peroxynitrite donor, induces Bcl-2-sensitive, p53-independent apoptosis in murine bone marrow cells. Biochem Pharmacol. 2007 Oct 1;74(7):1039-49 [4]. Asmawi MZ, Moilanen E, Annala K, Rahkonen P, Kankaanranta H. Effects of nitric oxide donors GEA 3162 and SIN-1 on ethanol-induced gastric ulceration in rats. Eur J Pharmacol. 1999 Jul 28;378(1):123-7.
CoA	CoA of GEA 3162

Smiles:	ClC1=CC=C([N+]2=NOC([NH-])=N2)C=C1Cl


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