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Product Information:

GDC0973

Cobimetinib (GDC-0973, RG7420) is a potent, selective and oral MEK1 inhibitor with an IC50 of 4.2 nM for MEK1.

Cat. No.: EX-A673    Purity: >98%
Chemical
Chemical structure of GDC0973


For research only, Do not use for Human!

SizeUnit Price (US$)StockQuantityOrder
250mg485In-stock
500mg750In-stock
1g1250In-stock
5g3800In-stock
10g5800In-stock


SynonymsXL518
Synonyms 2Cobimetinib
CAS No.934660-93-2
Purity>98%
FormulaC21H21F3IN3O2
Mol Weight531.31
Colorwhite
Statesolid powder
SolubilitySoluble in DMSO
Shelf Life>2 years if stored properly
StoragePowder -20℃ 2 years; In solvent -20℃ 1 month;
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.

[2]. Corazao-Rozas P, et al. Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors. Oncotarget. 2016 Feb 29. doi: 10.18632/oncotarget.7790.

CoACoA of GDC0973
Smiles:OC1(CN(C1)C(=O)C1=C(NC2=C(F)C=C(I)C=C2)C(F)=C(F)C=C1)[C@@H]1CCCCN1

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