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Product Information:

GB-1211

Selvigaltin (GB1211) is an orally available galectin-3 (Gal-3) inhibitor .

Cat. No.: EX-A8646    Purity: >98%
Chemical
Chemical structure of GB-1211


For research only, Do not use for Human!

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SynonymsSelvigaltin
CAS No.1978336-95-6
Purity>98%
FormulaC19H16BrF3N4O4S
Mol Weight533.319
ColorWhite to off-white
Statesolid powder
SolubilityDMSO : 12.5 mg/mL 
Shelf Life>3 years if stored properly
Storage -20°C, stored under nitrogen
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1].Slack RJ, et al. The therapeutic potential of galectin-3 inhibition in fibrotic disease. Int J Biochem Cell Biol. 2021 Jan;130:105881.

[2].Zetterberg Fredrik, et al. Preparation of galactosides as galectins inhibitors. WO2020078808+A1. 2020 April 23.

[3].Comeglio P, et al. The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis. Front Pharmacol. 2024 Jul 31;15:1430109.

[4].Aslanis V, et al. Single‑Dose Pharmacokinetics and Safety of the Oral Galectin‑3 Inhibitor, Selvigaltin (GB1211), in Participants with Hepatic Impairment. Clin Drug Investig. 2024 Oct 2.

CoACoA of GB-1211
Smiles:O[C@@H]([C@H](O1)SC2=CN=CC(Br)=C2)[C@](N3C=C(C(C=C4F)=CC(F)=C4F)N=N3)([H])[C@H]([C@H]1CO)O

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