Galiellalactone

Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer.


Cat. No.: EX-A14244	Purity: >98%

	Chemical structure of Galiellalactone

For research only, Do not use for Human!

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CAS No.	133613-71-5
Purity	>98%
Formula	C11H14O3
Mol Weight	194.2271
Color	White to off-white
State	Solid
Shelf Life	>3 years if stored properly
Storage	Powder -20°C, 3 years; In solvent -20°C, 1 month.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Hellsten R, et, al. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. Prostate. 2008 Feb 15; 68(3): 269-80. [2]. Doncow DN, et, al. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem. 2014 Jun 6; 289(23): 15969-78. [3]. Weidler M, et, al. Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 2000 Oct 27; 484(1): 1-6.
CoA	CoA of Galiellalactone

Smiles:	CC1CC2CCC3C2(C(=C1)C(=O)O3)O


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