Gaboxadol hydrochloride

Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM). Gaboxadol hydrochloride is a non-opioid agent.


Cat. No.: EX-A11083	Purity: >98%

	Chemical structure of Gaboxadol hydrochloride

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
1g	190	In-stock
5g	760	In-stock
10g	2320	In-stock
25g	4420	In-stock
50g	6920	In-stock

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Synonyms	THIP hydrochloride
Synonyms 2	Lu 02-030 hydrochloride
CAS No.	85118-33-8
Purity	>98%
Formula	C6H9ClN2O2
Mol Weight	176.601
Color	White to off-white
State	Solid
Solubility	H2O : ? 100 mg/mL DMSO : 75 mg/mL
Shelf Life	>3 years if stored properly
Storage	Powder 4°C, sealed storage, away from moisture and light; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Johnston GA, et al. Neurochemicals for the investigation of GABA(C) receptors. Neurochem Res. 2010 Dec;35(12):1970-7. [2]. Cogram P, et al. Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome.Front Behav Neurosci. 2019 Jun 25;13:141. [3]. Larsen M, et al. Intestinal gaboxadol absorption via PAT1 (SLC36A1): modified absorption in vivo following co-administration of L-tryptophan.Br J Pharmacol. 2009 Aug;157(8):1380-9.
CoA	CoA of Gaboxadol hydrochloride

Smiles:	O=C1C2=C(CNCC2)ON1.Cl


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