G7-18NATE

G7-18NATE is a peptide inhibitor of Grb7. HY-P10224 binds to the Grb7-SH2 domain with micromolar affinity (KD = 18.1 μM). G7-18NATE inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines .


Cat. No.: EX-A9842	Purity: >98%

	Chemical structure of G7-18NATE

For research only, Do not use for Human!

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CAS No.	936728-13-1
Purity	>98%
Formula	C67H80N14O19S
Mol Weight	1417.5
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739. [2]. Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15.
CoA	CoA of G7-18NATE

Smiles:	C(C=1C=2C(NC1)=CC=CC2)[C@H]3C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC5=CC=C(O)C=C5)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N7[C@](C(=O)N[C@H](C(N)=O)CSCC(=O)N3)(CCC7)[H]


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