G140

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity.


Cat. No.: EX-A5169	Purity: >98%

	Chemical structure of G140

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
25mg	685	In-stock
50mg	985	In-stock
100mg	1285	In-stock
200mg	1885	In-stock
1g	2885	In-stock

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CAS No.	2369751-07-3
Purity	>98%
Formula	C17H16Cl2N4O2
Mol Weight	379.241
Color	White to off-white
State	solid powder
Solubility	Soluble in DMSO 250 mg/mL
Shelf Life	>2 years if stored properly
Storage	Powder -20℃ 2 years; In solvent -20℃ 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.
CoA	CoA of G140

Smiles:	OCC(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)=O


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