G-6599

G-6599 is a monovalent molecular glue-like degrader of SMARCA2/SMARCA4. G-6599 covalently binds to a specific cysteine residue of the E3 ligase FBXO22 in a biotransformation-independent manner, promotes the formation of a ternary complex with SMARCA2/A4, and achieves efficient and specific degradation of the two proteins via the ubiquitin-proteasome pathway. G-6599 is applicable to the research of androgen-dependent prostate cancer and mutant non-small cell lung cancer .


Cat. No.: EX-A16630	Purity: >98%

	Chemical structure of G-6599

For research only, Do not use for Human!

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CAS No.	2901806-51-5
Purity	>98%
Formula	C31H37N7O
Mol Weight	523.6718
Color	White to light yellow
State	solid
Solubility	DMSO : ? 100 mg/mL
Shelf Life	>2 years if stored properly
Storage	4°C, sealed storage, away from moisture
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1].Villemure E, et al. Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22. Nat Commun. 2025 Nov 3;16(1):9679.
CoA	CoA of G-6599

Smiles:	OC1=CC=CC=C1C2=CC(N3CC4N(C5=CC(C#CCCN6CCCCCC6)=NC=C5)C(CC4)C3)=C(N)N=N2


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