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Product Information:

G-5555 hydrochloride

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

Cat. No.: EX-A13265A    Purity: >98%
Chemical
Chemical structure of G-5555 hydrochloride


For research only, Do not use for Human!

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CAS No.2319590-15-1
Purity>98%
FormulaC25H26Cl2N6O3
Mol Weight529.418
ColorLight yellow to yellow
StateSolid
SolubilityDMSO : 100 mg/mL H2O : 16.67 mg/mL
Shelf Life>3 years if stored properly
StoragePowder 4°C, sealed storage, away from moisture. In solvent -20°C, 1 month
ShippingShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
 
 
Reference:  

[1]. Ndubaku CO, et al. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.

[2]. Rudolph J, et al. Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem. 2016 Jun 9;59(11):5520-41.

CoACoA of G-5555 hydrochloride
Smiles:C(N1C=2C(C=C(C1=O)C3=C(Cl)C=C(C=C3)C=4N=C(C)C=CC4)=CN=C(NC)N2)[C@@H]5OC[C@@H](N)CO5.Cl

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