FXR agonist 15

FXR agonist 15 is a selective, potent and orally active farnesoid X receptor (FXR) agonist with EC50 of 0.76 μM. FXR agonist 15 exhibits no obvious activation on other nuclear receptors including LXRα/β, PXR, PPARα/β/γ, THR-β, with EC50 values all >10 μM. FXR agonist 15 can alleviate steatosis, lobular inflammation, hepatocyte ballooning and liver fibrosis. FXR agonist 15 can be used for the research of nonalcoholic steatohepatitis (NASH).


Cat. No.: EX-A16509	Purity: >98%

	Chemical structure of FXR agonist 15

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock	Quantity	Order
25mg	996	inquire
100mg	1598	inquire

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CAS No.	2991276-14-1
Purity	>98%
Formula	C24H22Cl2FNO5S
Mol Weight	526.405
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Wang W, et al. Design, synthesis, and biological studies of novel sulfonamide derivatives as farnesoid X receptor agonists. Eur J Med Chem. 2023;258:115614.
CoA	CoA of FXR agonist 15

Smiles:	FC1=CC(C2=CC=C(N(S(=O)(C3=C(Cl)C=CC=C3Cl)=O)CC(C)C)C=C2)=CC=C1OCC(O)=O


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