Furin Inhibitor II

Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3].


Cat. No.: EX-A14602	Purity: >98%

	Chemical structure of Furin Inhibitor II

For research only, Do not use for Human!

Size	Unit Price (US$)	Stock
250mg	360	In-stock
500mg	720	In-stock
1g	1090	In-stock

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Synonyms	Furin Inhibitor II
CAS No.	673202-67-0
Purity	>98%
Formula	C36H75N25O6
Mol Weight	954.1446
Color	White to off-white
State	Solid
Solubility	soluble in DMSO
Shelf Life	>2 years if stored properly
Storage	Powder -80℃, 2 years; -20℃, 1 year; In solvent -20℃, 1 month;
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. [2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. [3]. Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9.
CoA	CoA of Furin Inhibitor II

Smiles:	C(C[C@H](C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CCCN=C(N)N)C(=O)N)N)CN=C(N)N


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