FTO-IN-10

FTO-IN-10 (compound 7) is a potent human demethylase FTO (the fat mass and obesity-associated protein) inhibitor with an IC50 of 4.5 μM. FTO-IN-10 enters the FTO’s structural domain II binding pocket through hydrophobic and hydrogen bonding interactions. FTO-IN-10 induces DNA damage and autophagic cell death in A549 cells.


Cat. No.: EX-A12877	Purity: >98%

	Chemical structure of FTO-IN-10

For research only, Do not use for Human!

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CAS No.	3054640-55-7
Purity	>98%
Formula	C22H20N4O3
Mol Weight	388.4192
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Reference:	[1]. Chao Ge, et al. Novel 1,8-Naphthalimide Derivatives As Antitumor Agents and Potent Demethylase Inhibitors. ACS Med. Chem. Lett. 2023.
CoA	CoA of FTO-IN-10

Smiles:	O=C(NC1=CC2=CC=CC=3C(=O)N(C(=O)C(=C1)C23)CCN(C)C)C4=NC=CC=C4


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